Yazar "Erdem, Sultan Sibel" için listeleme
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Blood accessibility to fibrin in venous thrombosis is thrombus age-dependent and predicts fibrinolytic efficacy: An in vivo fibrin molecular imaging study
Stein-Merlob, Ashley; Kessinger, Chase; Erdem, Sultan Sibel; Zelada, Henry; Hilderbrand, Scott; Lin, Charles; Jaff, Michael; Jaff, Michael; Reed, Guy; Henke, Peter; McCarthy, Jason; Jaffer, Farouc Amin (Ivyspring International Publisher, 2015)Fibrinolytic therapy of venous thromboembolism (VTE) is increasingly utilized, yet limited knowledge is available regarding in vivo mechanisms that govern fibrinolytic efficacy. In particular, it is unknown how age-dependent ... -
Compliance of medical biochemistry education in medical schools with national core education program 2014
Erdem, Sultan Sibel; Yiğitbaşı, Türkan; Yiğit, Pakize; Emekli, Nesrin (Walter De Gruyter Gmbh, 2019)Background: Medical school curriculums are not standardized in Turkey and around the world, which results in great diversity in education. National Core Education Program (NCEP) has been prepared as a frame program and the ... -
Design of dense brush conformation bearing gold nanoparticles as theranostic agent for cancer
Verimli, Nihan; Demiral, Ayşegül; Yılmaz, Hülya; Çulha, Mustafa; Erdem, Sultan Sibel (Springer, 2019)Dense brush conformation–bearing theranostic agents are emerging as drug delivery systems due to their higher ability to escape from reticuloendothelial system uptake which prolongs their in vivo circulation time. With the ... -
Development of light and pH-dual responsive self-quenching theranostic SPION to make EGFR overexpressing micro tumors glow and destroy
Verimli, Nihan; Goralı, Selen İrem; Abişoğlu, Beyza; Altan, Cem Levent; Sucu, Bilgesu Onur; Karataş, Ersin; Tülek, Ahmet; Bayraktaroğlu, Çiğdem; Beker, Mustafa Çağlar; Erdem, Sultan Sibel (Elsevier B.V., 2023)Drug resistant and undetectable tumors easily escape treatment leading metastases and/or recurrence of the lethal disease. Therefore, it is vital to diagnose and destroy micro tumors using simple yet novel approaches. Here, ... -
Evaluation of digoxin as anti-cancer agent in colon cancer cell line
Mohamud, Kalif Mohamed (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2017)Colorectal cancer is a common disease all over the world and the occurrence of colorectal cancer is increasing in developing countries. Generally the occurence and mortality of colorectal cancer are substantially advanced ... -
Guiding empiric treatment for serious bacterial infections via point of care beta-lactamase characterization
Palanisami, Akilan; Khan, Shazia; Erdem, Sultan Sibel; Hasan, Tayyaba (Ieee-Inst Electrical Electronics Engineers Inc, 2016)Fever is one of the most common symptoms of illness in infants and represents a clinical challenge due to the potential for serious bacterial infection. As delayed treatment for these infections has been correlated with ... -
Imaging Granzyme B activity assesses immune-mediated myocarditis
Konishi, Masanori; Erdem, Sultan Sibel; Weissleder, Ralph; Lichtman, Andrew; McCarthy, Jason; Libby, Peter (Lippincott Williams and Wilkins, 2015)Rationale: The development of molecular imaging approaches that assess specific immunopathologic mechanisms can advance the study of myocarditis. Objective: This study validates a novel molecular imaging tool that enables ... -
Intravascular fibrin molecular imaging improves the detection of unhealed stents assessed by optical coherence tomography in vivo
Hara, Tetsuya; Ughi, Giovanni J.; McCarthy, Jason R.; Erdem, Sultan Sibel; Mauskapf, Adam; Lyon, Samantha C.; Fard, Ali M.; Edelman, Elazer R.; Tearney, Guillermo J.; Jaffer, Farouc A. (Oxford University Press, 2017)Aims Fibrin deposition and absent endothelium characterize unhealed stents that are at heightened risk of stent thrombosis. Optical coherence tomography (OCT) is increasingly used for assessing stent tissue coverage as a ... -
Manyetik nanoparçacıkların pankreas kanser hücre hattına özgü DNA nanoparçacıkları ile modifikasyonu yoluyla hücreye hedeflendirilmesi
Keçeloğlu, Gizem (İstanbul Medipol Üniversitesi Sağlık Bilimleri Enstitüsü, 2020)Kanser türüne özel geliştirilmeye çalışılan kişiselleştirilmiş tıp uygulamaları, aptamer, ligand ve antikor gibi ajanların afiniteye bağlı olarak aktif hedeflemede kullanılmasını içerir. Bu yaklaşım, spesifik bir hücre ... -
Near-infrared dyes and their use in medical science
Erdem, Sultan Sibel (2016)Targeted imaging (diagnosis) and therapy using near-infrared (NIR) dyes can be accomplished with the help of the data obtained from fluorescence emission of the fluorophores and play an important role particularly in deep ... -
Over kanseri̇ne yöneli̇k fotodi̇nami̇k terapi̇ temelli̇ kombi̇nasyon terapi̇ uygulaması
Erdem, Sultan Sibel; Akgül Obeidin, Vildan; Parlar, Rabia Edibe; Şahin, Ubeydullah (Zeynep Kamil Kadın ve Çocuk Hastalıkları Eğitim ve Araştırma Hastanesi, 2018)Kanser, tüm dünyada olduğu gibi ülkemizde de en ölümcül hastalıkların başında gelmektedir. Kanserin, lokal, minimum yan etkiyle ve hedefe yönelik olarak tedavisi hasta için büyük önem taşımaktadır. Fotodinamik Terapi (FDT), ... -
A rational design of multi-functional nanoplatform: Fluorescent-based “off-on” theranostic gold nanoparticles modified with D-α-Tocopherol succinate
Demiral, Ayşegül; Verimli, Nihan; Goralı, İrem; Yılmaz, Hülya; Çulha, Mustafa; Erdem, Sultan Sibel (Elsevier B.V., 2021)It is crucial to develop nanocarrier systems to detect and treat drug-resistant micro tumors to prevent recurrence and/or metastasis of cancer. Due to their exceptional features such as biocompatibility, easy surface ... -
Skov-3 over kanseri hücre hattında fotodinamik terapi uygulaması
Sürdürülen sayısız araştırmaya ve geliştirilen ilaçlara rağmen günümüzde kanser hala milyonlarca insanın ölümüne neden olan hastalıkların başında gelmektedir. Over kanseri en ölümcül kanserlerden biri olup kadınlarda en ... -
Stimuli-responsive theranostic system: A promising approach for augmented multimodal imaging and efficient drug release
Demiral, Ayşegül; Goralı, S. İrem; Yılmaz, Hülya; Verimli, Nihan; Çulha, Mustafa; Erdem, Sultan Sibel (Elsevier B.V., 2022)Destruction of drug resistant and invisible micro-tumors requires innovative screening and treatment modalities. Theranostic nanosystems offering multimodal imaging and therapy are attractive platforms with potential to ... -
Verteporfin mediated sequence dependent combination therapy against ovarian cancer cell line
Erdem, Sultan Sibel; Akgül Obeidin, Vildan; Yiğitbaşı, Türkan; Tümer, S. Serranur; Yiğit, Pakize (Elsevier Science Sa, 2018)Ovarian Cancer is one of the deadliest gynecological cancer showing high resistance to chemotherapy. Non overlapping and synergistic combination therapies are the best option to overcome this multi-pathological silent ...